Stress signaling etches heritable marks on chromatin.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21703443.
- Also identified by DOI 10.1016/j.cell.2011.06.009.
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Abstract
Transgenerational inheritance of epigenetic states allows organisms to pass on adaptive responses to the environment to their offspring. Seong et al. (2011) now reveal how stress-induced signaling through dATF-2 disrupts heterochromatin and leaves heritable marks that influence patterns of gene expression in subsequent generations.