Stuck in the middle: drugging the ubiquitin system at the e2 step.
review · Level V
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- Record sourced from PubMed, PMID 21703444.
- Also identified by DOI 10.1016/j.cell.2011.06.002.
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Abstract
The discovery of a small-molecule allosteric inhibitor of the CDC34 ubiquitin-conjugating enzyme (E2) by Ceccarelli et al. raises the possibility that it will be generally feasible to selectively inhibit ubiquitin transfer at this central step in the ubiquitin pathway.