Biologic and plastic effects of experimental traumatic brain injury treatment paradigms and their relevance to clinical rehabilitation.

Garcia, Alexandra N; Shah, Mansi A; Dixon, C Edward; Wagner, Amy K; Kline, Anthony E · PM R · 2011

review · Level V

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Abstract

Neuroplastic changes, whether induced by traumatic brain injury (TBI) or therapeutic interventions, alter neurobehavioral outcome. Here we present several treatment strategies that have been evaluated by using experimental TBI models and discuss potential mechanisms of action (ie, plasticity) and how such changes affect function.

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