Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt-Jakob disease.
basic_science · Level V
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Abstract
Cerebellar kuru plaques in 2 cases of Creutzfeldt-Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin-positive, tau-negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt-Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.
Medical subject headings
- Cerebellum
- Creutzfeldt-Jakob Syndrome
- Ubiquitins