WNT/β-catenin signaling in polycystic kidney disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21720305.
- Also identified by DOI 10.1038/ki.2011.87.
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Abstract
Cystic kidney diseases have been linked to defective WNT signal transduction. Perturbations of cystic disease genes cause activation of canonical WNT/β-catenin/TCF/Lef1 signaling in model organisms and cultured cells. Inappropriate levels of WNT/β-catenin signaling cause renal cyst formation in mice. These observations have prompted the idea that an activation of WNT/β-catenin signaling may constitute a common causative event in cyst formation. Now this view is challenged by key genetic mouse models of cystic kidney disease that do not display WNT/β-catenin activity in cyst-lining epithelia.
Medical subject headings
- Cysts
- Polycystic Kidney, Autosomal Dominant
- TCF Transcription Factors
- beta Catenin