Nonsteroidal antiinflammatory drug withdrawal in patients with stable rheumatoid arthritis.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 21724698.
- Also identified by DOI 10.3899/jrheum.101162.
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Abstract
To evaluate the effect of nonsteroidal antiinflammatory drug (NSAID) withdrawal on blood pressure (BP), 44-joint Disease Activity Score (DAS44), and functional assessments in patients with stable rheumatoid arthritis (RA). NSAID was withdrawn from 30 patients with stable RA (DAS44 ≤ 2.8). Other prescribed medication continued. Clinical and laboratory measures were taken at baseline, 6 weeks, and 12 weeks. No participants required NSAID reintroduction during the study period. Significant improvement in systolic BP was noted: maximal median reduction was 7 mm Hg (baseline to 12 weeks). There was no significant deterioration in DAS44 or function. Eleven participants required additional intervention. NSAID withdrawal resulted in improvement in BP without loss of disease control.
Medical subject headings
- Anti-Inflammatory Agents, Non-Steroidal
- Arthritis, Rheumatoid
- Blood Pressure