Functional ultrasound imaging of the brain.

Macé, Emilie; Montaldo, Gabriel; Cohen, Ivan; Baulac, Michel; Fink, Mathias; Tanter, Mickael · Nat Methods · 2011

basic_science · Level V

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Abstract

We present functional ultrasound (fUS), a method for imaging transient changes in blood volume in the whole brain at better spatiotemporal resolution than with other functional brain imaging modalities. fUS uses plane-wave illumination at high frame rate and can measure blood volumes in smaller vessels than previous ultrasound methods. fUS identifies regions of brain activation and was used to image whisker-evoked cortical and thalamic responses and the propagation of epileptiform seizures in the rat brain.

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