Wnt to notch relay signaling induces definitive hematopoiesis.
basic_science · Level V
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- Record sourced from PubMed, PMID 21726826.
- Also identified by DOI 10.1016/j.stem.2011.06.011.
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Abstract
The molecular mechanisms specifying hematopoietic stem cells (HSCs) in the vertebrate embryo remain poorly understood. Recently in Nature, Traver and colleagues demonstrate that timed wnt to Notch relay signaling across multiple cell types serves as an early upstream mechanism of HSC induction in zebrafish (Clements et al., 2011).