Neuroendocrine carcinoma of the oral cavity.

Benning, T L; Vollmer, R T; Crain, B J; Shelburne, J D · Mod Pathol · 1990

case_report · Level V

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Abstract

We report the clinical and pathologic features of a small cell neuroendocrine carcinoma arising in the oral cavity of a 63-year-old man. The tumor stained positively with neuron-specific enolase and had dense core granules ultrastructurally. Chemotherapy ordinarily given for pulmonary small cell carcinoma induced a clinical remission. When the tumor recurred 8 mo later, focal squamous differentiation was present within the neuroendocrine carcinoma. The patient died 2.5 yr after presentation.

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