A flip turn for membrane protein insertion.
basic_science · Level V
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- Record sourced from PubMed, PMID 21729778.
- Also identified by DOI 10.1016/j.cell.2011.06.028 and PMC identifier 4162087.
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Abstract
The transmembrane domains in a membrane protein must be recognized and correctly oriented before their insertion into the lipid bilayer. Devaraneni et al. (2011) generate snapshots at different stages of membrane protein biogenesis, revealing a dynamic set of steps that imply an unexpectedly flexible membrane insertion machinery.