Simulating systems genetics data with SysGenSIM.
basic_science · Level V
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- Record sourced from PubMed, PMID 21737438.
- Also identified by DOI 10.1093/bioinformatics/btr407 and PMC identifier 3157927.
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Abstract
SysGenSIM is a software package to simulate Systems Genetics (SG) experiments in model organisms, for the purpose of evaluating and comparing statistical and computational methods and their implementations for analyses of SG data [e.g. methods for expression quantitative trait loci (eQTL) mapping and network inference]. SysGenSIM allows the user to select a variety of network topologies, genetic and kinetic parameters to simulate SG data ( genotyping, gene expression and phenotyping) with large gene networks with thousands of nodes. The software is encoded in MATLAB, and a user-friendly graphical user interface is provided. The open-source software code and user manual can be downloaded at: http://sysgensim.sourceforge.net/ alf@crs4.it.
Medical subject headings
- Gene Regulatory Networks
- Genotype
- Software