Corpus callosum and experimental stroke: studies in callosotomized rats and acallosal mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21737800.
- Also identified by DOI 10.1161/STROKEAHA.111.613349 and PMC identifier 3164743.
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Abstract
Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke. We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice. Neither callosotomy in rats nor callosal agenesis in mice improved infarct volume or behavioral outcome after middle cerebral artery occlusion. These findings argue against a role for transcallosal projections in exacerbating focal cerebral ischemia.
Medical subject headings
- Brain Infarction
- Corpus Callosum
- Stroke