Synthesis and characterization of hierarchically macroporous and mesoporous CaO-MO-SiO(2)-P(2)O(5) (M=Mg, Zn, Sr) bioactive glass scaffolds.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21742065.
- Also identified by DOI 10.1016/j.actbio.2011.06.029.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Mg-, Zn- and Sr-doped hierarchically macroporous and mesoporous CaO-MO-SiO(2)-P(2)O(5) (M=Mg, Zn or Sr) bioactive glass (HMMBG) scaffolds were synthesized using the non-ionic block copolymer EO(20)PO(70)EO(20) and polyurethane sponges as cotemplates. The Mg-, Zn- or Sr-doped HMMBG scaffolds showed no distinct difference in phase composition, macroporous structure or pore volume from the HMMBG scaffolds without Mg, Zn or Sr. The Mg-, Zn- and Sr-doped HMMBG scaffolds showed no cytotoxicity. The gradual release of Ca, P, Si, Mg, Zn and Sr into the culture medium from these scaffolds contributed to the enhancement of the proliferation and ALP activity of mesenchymal stem cells (MSCs). The Mg-, Zn- and Sr-doped HMMBG scaffolds may be used as bone substitute materials.
Medical subject headings
- Biocompatible Materials
- Glass
- Oxides
- Tissue Scaffolds