Incremental impact of adding boys to current human papillomavirus vaccination programs: role of herd immunity.
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Where this comes from
- Record sourced from PubMed, PMID 21742835.
- Also identified by DOI 10.1093/infdis/jir285.
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Abstract
Our aim was to examine the potential incremental impact of vaccinating boys against human papillomavirus (HPV) on vaccine-type infection in females and males, using an individual-based HPV transmission-dynamic model. Under base assumptions (vaccine efficacy = 99%, duration of protection = 20 years, coverage = 70%), vaccinating 12-year-old boys, in addition to girls, resulted in an incremental reduction in HPV-16/18 (HPV-6/11) incidence over 70 years of 16% (3%) in females and 23% (4%) in males. The benefit of vaccinating boys decreased with improved vaccination coverage in girls. Given the important predicted herd immunity impact of vaccinating girls under moderate to high vaccine coverage, the potential incremental gains of vaccinating boys are limited.
Medical subject headings
- Condylomata Acuminata
- Papillomavirus Vaccines
- Uterine Cervical Neoplasms
- Vaccination