Vaccine design reaches the atomic level.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 21753119.
- Also identified by DOI 10.1126/scitranslmed.3002807 and PMC identifier 8513375.
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Abstract
The genetic diversity of pathogens presents a challenge to the development of broadly effective vaccines. In this issue, Scarselli et al. combine atomic-level structural information with genomics and classical vaccinology to design a single immunogen that elicits protective immunity against more than 300 natural variants of the bacterial pathogen meningococcus B. This accomplishment provides a glimpse of the power of structure-based vaccine design to create immunogens capable of eliciting protective responses against genetically diverse pathogens.
Medical subject headings
- Antigens, Bacterial
- Drug Design
- Immunity
- Neisseria meningitidis