Clinical and infection control implications of Clostridium difficile infection with negative enzyme immunoassay for toxin.

Guerrero, Dubert M; Chou, Christina; Jury, Lucy A; Nerandzic, Michelle M; Cadnum, Jennifer C; Donskey, Curtis J · Clin Infect Dis · 2011

prospective_cohort · Level II

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Abstract

In a prospective study of 132 patients with a diagnosis of Clostridium difficile infection (CDI) by polymerase chain reaction, 43 (32%) had enzyme immunoassay (EIA) results negative for toxin. EIA-negative patients with CDI did not differ in clinical presentation from EIA-positive patients and presented a similar risk for transmission of spores.

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