Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21771911.
- Also identified by DOI 10.1158/0008-5472.CAN-11-0923.
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Abstract
Acquired resistance to targeted therapies threatens the value of these otherwise very promising agents. The recent description of resistance to the Hedgehog pathway inhibitor vismodegib (GDC-0449) in a medulloblastoma patient who had a dramatic initial response has spurred efforts to understand potential mechanisms of drug resistance. Elucidating these mechanisms will play a significant role in informing strategies to overcome this meaningful limitation.
Medical subject headings
- Antineoplastic Agents
- Drug Resistance, Neoplasm
- Hedgehog Proteins
- Molecular Targeted Therapy
- Neoplasm Proteins
- Receptors, G-Protein-Coupled
- Signal Transduction