Glioma development: where did it all go wrong?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21784240.
- Also identified by DOI 10.1016/j.cell.2011.06.047.
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Abstract
Investigating the family tree of a tumor to identify its cellular origins is a daunting task. Liu et al. (2011) now use an elegant lineage tracing technique (MADM) to visualize glioma from its earliest stages. They show that mutations originally induced in neural stem cells lie dormant and only trigger malignant transformation following differentiation into oligodendrocyte precursor cells.