Tethered genes get checked during replication.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21784241.
- Also identified by DOI 10.1016/j.cell.2011.06.046.
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Abstract
Although events associated with replication stress have long formed the cornerstone of checkpoint activation, questions remain about how cells maintain the integrity of replicating genomes. Now, Bermejo et al. (2011) identify a mechanism directly linking checkpoint function to the relief of topological tension at nuclear pore tethered genes.