Antibody repertoire: embracing diversity.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 21795586.
- Also identified by DOI 10.1126/scitranslmed.3002694.
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Abstract
In this Perspective, we discuss two papers that show that the breadth of the antibody response to vaccines could be manipulated by the use of particular vaccine adjuvants that stimulate innate immune mechanisms. The ability to increase the repertoire of antibodies induced by a vaccine may help to control variable pathogens that alter their exposed antigens to evade the immune system.
Medical subject headings
- Adjuvants, Immunologic
- Antibodies, Protozoan
- Influenza Vaccines
- Malaria Vaccines
- Polysorbates
- Squalene
- Toll-Like Receptors