Bacterial genomic detection within cerebrospinal fluid of patients with meningococcal disease is influenced by microbial and host characteristics.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 21798855.
- Also identified by DOI 10.1093/cid/cir433.
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Abstract
Among 384 patients with confirmed meningococcal disease, the likelihood of detecting Neisseria meningitidis DNA in cerebrospinal fluid (CSF) increased with age, serogroup B infection, and prehospitalization antibiotic treatment. Plasma and CSF genomic bacterial loads of non-B N. meningitidis serogroups correlated significantly. Serogroup B-infected patients with genotype TNF2 (-308A) had significantly higher CSF bacterial loads.
Medical subject headings
- DNA, Bacterial
- Meningitis, Meningococcal
- Neisseria meningitidis