The complex world of kidney microRNAs.
Level V
Where this comes from
- Record sourced from PubMed, PMID 21799505.
- Also identified by DOI 10.1038/ki.2011.165.
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Abstract
MicroRNAs are short noncoding RNAs that usually reduce translation of messenger RNAs. Changes in microRNA-192 (miR-192) are reported in states of renal fibrosis. New evidence supports a role for miR-192 and its target miR-200b/c in transforming growth factor-β1 regulation of its own expression and that of collagens in mesangial cells, with a possible role in diabetic nephropathy. As there is controversy on the role of these microRNAs in diabetic nephropathy, more work is needed.
Medical subject headings
- Diabetes Mellitus, Experimental
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
- Mesangial Cells
- MicroRNAs
- Transforming Growth Factor beta1