Osteopontin functionalization of hydroxyapatite nanoparticles in a PDLLA matrix promotes bone formation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21800419.
- Also identified by DOI 10.1002/jbm.a.33166 and PMC identifier 4495906.
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Abstract
We studied the osteoconductive tissue response of hydroxyapatite (HA) nanoparticles functionalized with osteopontin (OPN) in a matrix of poly-D,L-lactic-acid (PDLLA). In a canine endosseus 0.75-mm gap implant model, we tested the osteointegrative impact of the OPN functionalized composite as an implant coating, and a non-functionalized composite was used as reference control. During the four weeks of observation, the OPN functionalized composite coating significantly increased the formation of new bone in the porosities of the implant, but no differences were observed in the gap. The study provides evidence of its potential use either alone or in combination with other osteoconductive compounds.
Medical subject headings
- Bone Regeneration
- Bone Substitutes
- Coated Materials, Biocompatible
- Durapatite
- Lactic Acid
- Nanoparticles
- Osteopontin
- Polymers