Nanoengineering the heart: conductive scaffolds enhance connexin 43 expression.
basic_science · Level V
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- Record sourced from PubMed, PMID 21800912.
- Also identified by DOI 10.1021/nl201514a.
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Abstract
Scaffolds that couple electrical and elastic properties may be valuable for cardiac cell function. However, existing conductive materials do not mimic physiological properties. We prepared and characterized a tunable, hybrid hydrogel scaffold based on Au nanoparticles homogeneously synthesized throughout a polymer templated gel. Conductive gels had Young's moduli more similar to myocardium relative to polyaniline and polypyrrole, by 1-4 orders of magnitude. Neonatal rat cardiomyocytes exhibited increased expression of connexin 43 on hybrid scaffolds relative to HEMA with or without electrical stimulation.
Medical subject headings
- Connexin 43
- Gene Expression Regulation
- Heart
- Myocardium
- Myocytes, Cardiac
- Nanotechnology