The smoking gun in nicotine-induced anorexia.
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- Record sourced from PubMed, PMID 21803282.
- Also identified by DOI 10.1016/j.cmet.2011.07.006 and PMC identifier 3787252.
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Abstract
Hypothalamic pro-opiomelanocortin (POMC) neurons are the major source of anorectic melanocortin peptides in the brain. A recent study (Mineur et al., 2011) demonstrates that nicotine directly stimulates arcuate POMC neurons through nicotinic acetylcholinergic α3β4 receptors, suggesting a new mechanism to understand the inverse relationship between tobacco smoking and body weight.