Aged worms erase epigenetic history.
basic_science · Level V
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- Record sourced from PubMed, PMID 21803283.
- Also identified by DOI 10.1016/j.cmet.2011.07.008.
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Abstract
Defining the molecular events that precipitate multisystem decline is an important component of aging research. In this issue, Jin et al. (2011) show that increased expression of the histone demethylase, utx-1, causes genome-wide decreases in histone H3K27 trimethylation, which includes the insulin/IGF-1 signaling (IIS) pathway that promotes aging.