Treatment outcomes of isoniazid-resistant tuberculosis patients, Western Cape Province, South Africa.

Jacobson, Karen R; Theron, Danie; Victor, Thomas C; Streicher, Elizabeth M; Warren, Robin M; Murray, Megan B · Clin Infect Dis · 2011

retrospective_cohort · Level III

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Abstract

We report treatment outcomes from a retrospective cohort of patients with isoniazid-monoresistant tuberculosis in rural South Africa. Sixteen percent of patients had poor outcomes, 61% of whom progressed to multidrug-resistant tuberculosis. These data reveal the need for early identification and aggressive follow-up of isoniazid monoresistance to increase treatment success.

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