A prion-like trigger of antiviral signaling.
basic_science · Level V
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- Record sourced from PubMed, PMID 21816270.
- Also identified by DOI 10.1016/j.cell.2011.07.018 and PMC identifier 4272580.
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Abstract
The MAVS protein plays a critical role in the assembly of an antiviral signaling complex on mitochondrial membranes. Hou et al. (2011) now report that virus infection induces a conformational change in MAVS, leading to the prion-like formation of functional self-aggregates that provide a sensitive trigger for antiviral signaling.