Tolerance induction by allogeneic hematopoietic stem cells.
editorial · Level V
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- Record sourced from PubMed, PMID 21816356.
- Also identified by DOI 10.1016/j.stem.2011.07.005.
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Abstract
In this issue of Cell Stem Cell, Zheng et al. (2011) report that HSCs expressing PD-L1 display enhanced engraftment in irradiated allogeneic recipients. Independently in Nature, Fujisaki et al. (2011) observe allogeneic HSCs persisting in proximity to regulatory T cells in nonirradiated recipients, further connecting HSCs and immune tolerance.