Pre-conception inter-pregnancy interval and risk of schizophrenia.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 21816866.
- Also identified by DOI 10.1192/bjp.bp.111.092916.
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Abstract
It is hypothesised that the risk of schizophrenia may be elevated in children conceived following a short inter-pregnancy interval, when maternal folate stores are still being replenished. We examined the relationship between inter-pregnancy interval and schizophrenia risk in a longitudinal, population-based cohort. Risk of schizophrenia was increased by approximately 150% in those born following a pregnancy interval of ≤6 months, but was not increased if the interval after birth of the participant, before conception of the subsequent sibling, was ≤6 months. These findings support the hypothesis that folate (or other micronutrient) deficiency during fetal development may be an important risk factor for schizophrenia.
Medical subject headings
- Birth Intervals
- Schizophrenia