Cancer-targeted optical imaging with fluorescent zinc oxide nanowires.
basic_science · Level V
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- Record sourced from PubMed, PMID 21823599.
- Also identified by DOI 10.1021/nl201782m and PMC identifier 3173586.
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Abstract
Herein we demonstrate that intrinsically fluorescent zinc oxide (ZnO) nanowires (NWs) can be adopted for molecularly targeted imaging of cancer cells, after they are functionalized to render water solubility, biocompatibility, and low cellular toxicity. Optical imaging of integrin α(v)β(3) on U87MG human glioblastoma cells was achieved with RGD peptide-conjugated green fluorescent ZnO NWs, which opened up new avenues of research for investigating ZnO NW-based agents in tumor vasculature-targeted molecular imaging and drug delivery.
Medical subject headings
- Metal Nanoparticles
- Microscopy, Fluorescence
- Nanowires
- Neoplasms
- Zinc Oxide