B-Myb, cancer, senescence, and microRNAs.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21828240.
- Also identified by DOI 10.1158/0008-5472.CAN-11-1044 and PMC identifier 3156249.
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Abstract
The transcription factor B-Myb plays a critical role in regulating gene expression and is implicated in controlling carcinogenesis and cellular senescence. Transcription of the B-Myb gene is regulated by retinoblastoma proteins acting directly on the B-Myb promoter. Recently, we found that microRNAs also control the abundance of B-Myb mRNA during senescence, adding another level of complexity to B-Myb regulation. This review focuses on the importance of B-Myb in cancer and senescence, with an emphasis on the regulation of B-Myb expression and activity.
Medical subject headings
- Cell Cycle Proteins
- Cellular Senescence
- MicroRNAs
- Neoplasms
- Trans-Activators