Cancer drug discovery faces the FACT.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21832237.
- Also identified by DOI 10.1126/scitranslmed.3002822.
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Abstract
In this issue of Science Translational Medicine, Gasparian et al. use a clever cell-based screen to identify a family of DNA-binding small molecules-curaxins-that inhibit tumor cell growth and division. The curaxins' mechanism of action pinpoints a new chromatin-remodeling factor as a therapeutic target for cancer.
Medical subject headings
- Antineoplastic Agents
- DNA-Binding Proteins
- High Mobility Group Proteins
- NF-kappa B
- Transcriptional Elongation Factors
- Tumor Suppressor Protein p53