Measuring forces between two single actin filaments during bundle formation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21838252.
- Also identified by DOI 10.1021/nl201630y.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Bundles of filamentous actin are dominant cytoskeletal structures, which play a crucial role in various cellular processes. As yet quantifying the fundamental interaction between two individual actin filaments forming the smallest possible bundle has not been realized. Applying holographic optical tweezers integrated with a microfluidic platform, we were able to measure the forces between two actin filaments during bundle formation. Quantitative analysis yields forces up to 0.2 pN depending on the concentration of bundling agents.
Medical subject headings
- Actins
- Biophysics