Chloroplast lipid droplet type II NAD(P)H quinone oxidoreductase is essential for prenylquinone metabolism and vitamin K1 accumulation.
basic_science · Level V
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- Record sourced from PubMed, PMID 21844348.
- Also identified by DOI 10.1073/pnas.1104790108 and PMC identifier 3161580.
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Abstract
Lipid droplets are ubiquitous cellular structures in eukaryotes and are required for lipid metabolism. Little is currently known about plant lipid droplets other than oil bodies. Here, we define dual roles for chloroplast lipid droplets (plastoglobules) in energy and prenylquinone metabolism. The prenylquinones--plastoquinone, plastochromanol-8, phylloquinone (vitamin K(1)), and tocopherol (vitamin E)--are partly stored in plastoglobules. This work shows that NAD(P)H dehydrogenase C1 (NDC1) (At5g08740), a type II NAD(P)H quinone oxidoreductase, associates with plastoglobules. NDC1 reduces a plastoquinone analog in vitro and affects the overall redox state of the total plastoquinone pool in vivo by reducing the plastoquinone reservoir of plastoglobules. Finally, NDC1 is required for normal plastochromanol-8 accumulation and is essential for vitamin K(1) production.
Medical subject headings
- Arabidopsis
- Arabidopsis Proteins
- Chloroplasts
- Chromans
- Lipids
- NADH, NADPH Oxidoreductases
- Plastoquinone
- Quinone Reductases
- Quinones
- Tocopherols
- Vitamin E
- Vitamin K 1