Relationship between serum RANKL and RANKL in bone.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21850548.
- Also identified by DOI 10.1007/s00198-011-1740-9.
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Abstract
It is now well accepted that the molecule receptor activator of NFκB ligand (RANKL) and osteoprotegerin play key roles in regulating physiological and pathological bone turnover. There are a large number of published reports of circulating RANKL levels in both health and pathology. However, interpretation of these data has been elusive, and the relationship between circulating RANKL and RANKL levels in bone is still not clear. This review explores this subject, documenting the possible origins of circulating RANKL and suggesting additional information that is required before serum RANKL levels can provide useful diagnostic or research information.
Medical subject headings
- Bone and Bones
- Osteoporosis
- Osteoprotegerin
- RANK Ligand