Insulin-like growth factor I - a novel biomarker of abdominal aortic aneurysms.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 21852164.
- Also identified by DOI 10.1016/j.ejvs.2011.07.013.
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Abstract
The study aimed to test the potential role of insulin-like growth factor I (IGF-I) and IGF-II as biomarkers for abdominal aortic aneurysm (AAA). IGF-I and II levels were analysed in 115 patients with screening diagnosed AAA kept under annual surveillance for 10 years. Serum IGF-I correlated positively with AAA size and growth rate (r = 0.23, P = 0.016 and r = 0.27, P = 0.004), persisting after adjustment for potential confounders. Serum IGF-I level predicted cases needing later surgery (AOC: 0.63; 95% confidence interval: 0.52-0.73). In this prospective, long-term study, baseline serum IGF-I correlated positively with AAA size and growth rate and predicted future need for preventive surgery.
Medical subject headings
- Aortic Aneurysm, Abdominal
- Insulin-Like Growth Factor I
- Insulin-Like Growth Factor II
- Population Surveillance