Early biological fixation of porous implant coated with paste-retaining recombinant bone morphogenetic protein 2.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21855270.
- Also identified by DOI 10.1016/j.arth.2011.06.017.
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Abstract
The aim of this study was to evaluate the period required for stable initial bone-implant fixation with recombinant human bone morphogenetic protein 2 (rhBMP-2) in the bone marrow of a rabbit model. The porous implants being coated with β-tricalcium phosphate/polylactide-polyethylene glycol paste with 15, 30, or 60 μg of rhBMP-2 (n = 10) were implanted into animals in 3 experimental groups. In 2 control groups, the test implants were coated without rhBMP or no paste. In all groups, the implant was inserted for 3 and 6 weeks. At 3 weeks after implantation, the BMP-treated implants in the 2 lower dose groups had significantly more bone ingrowth to the implant surface than did the control groups, and the greatest effect occurred in the 30-μg rhBMP-2 group animals.
Medical subject headings
- Bone Morphogenetic Protein 2
- Bone and Bones
- Coated Materials, Biocompatible
- Implants, Experimental
- Osseointegration
- Prosthesis Retention
- Transforming Growth Factor beta