Detecting biological network organization and functional gene orthologs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21856738.
- Also identified by DOI 10.1093/bioinformatics/btr485 and PMC identifier 3187654.
- Licence recorded as CC BY-NC.
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Abstract
We developed a package TripletSearch to compute relationships within triplets of genes based on Roundup, an orthologous gene database containing >1500 genomes. These relationships, derived from the coevolution of genes, provide valuable information in the detection of biological network organization from the local to the system level, in the inference of protein functions and in the identification of functional orthologs. To run the computation, users need to provide the GI IDs of the genes of interest. http://wall.hms.harvard.edu/sites/default/files/tripletSearch.tar.gz dpwall@hms.harvard.edu Supplementary data are available at Bioinformatics online.
Medical subject headings
- Genes, Bacterial
- Software