TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21862631.
- Also identified by DOI 10.1158/0008-5472.CAN-11-1194 and PMC identifier 3165102.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The Hedgehog (HH) and TGF-β signaling pathways represent essential regulators of cell proliferation and differentiation during embryogenesis. Pathway deregulation is a characteristic of various cancers. Recently, evidence for a convergence of these pathways at the level of the GLI2 transcription factor in the context of tumor initiation and progression to metastasis has emerged. This short review summarizes recent knowledge about GLI2 function and mechanisms of action downstream of TGF-β in cancer.
Medical subject headings
- Hedgehog Proteins
- Kruppel-Like Transcription Factors
- Neoplasms
- Nuclear Proteins
- Smad Proteins
- Transforming Growth Factor beta