SDRS--an algorithm for analyzing large-scale dose-response data.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21865301.
- Also identified by DOI 10.1093/bioinformatics/btr489 and PMC identifier 3187656.
- Licence recorded as CC BY-NC.
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Abstract
Dose-response information is critical to understanding drug effects, yet analytical methods for dose-response assays cannot cope with the dimensionality of large-scale screening data such as the microarray profiling data. To overcome this limitation, we developed and implemented the Sigmoidal Dose Response Search (SDRS) algorithm, a grid search-based method designed to handle large-scale dose-response data. This method not only calculates the pharmacological parameters for every assay, but also provides built-in statistic that enables downstream systematic analyses, such as characterizing dose response at the transcriptome level. Bio::SDRS is freely available from CPAN (www.cpan.org). ruiruji@gmail.com; bruc@acm.org Supplementary data is available at Bioinformatics online.
Medical subject headings
- Algorithms
- Gene Expression Profiling
- Transcriptome