Sputum inflammatory cells from patients with allergic rhinitis and asthma have decreased inflammasome gene expression.
Level V
Where this comes from
- Record sourced from PubMed, PMID 21868073.
- Also identified by DOI 10.1016/j.jaci.2011.08.012 and PMC identifier 3185200.
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Abstract
Deficits in inflammasomes, a key element of innate immunity, confer increased susceptibility to infection. We report that sputum cells from asthmatics have decreased expression of inflammasome factors, consistent with reports of increased infection risk in asthmatics.
Medical subject headings
- Asthma
- Gene Expression Regulation
- Inflammasomes
- Rhinitis
- Sputum