IL-10 neutralization promotes parasite clearance in splenic aspirate cells from patients with visceral leishmaniasis.
case_series · Level IV
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- Record sourced from PubMed, PMID 21881130.
- Also identified by DOI 10.1093/infdis/jir461 and PMC identifier 3164427.
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Abstract
The mechanisms underlying the failure to contain the growth of Leishmania parasites in human visceral leishmaniasis (VL) are not understood. L donovani amastigotes were quantified in cultured splenic aspirate cells to assess the function of IL-10 in lesional tissue ex vivo. In 67 patients with active VL, IL-10 neutralization promoted parasite killing in 73% and complete clearance in 30%, while 18% had more parasites and 9% did not change. The splenic cells secreted increased levels of both tumor necrosis factor α (TNFα) and interferon γ (IFNγ) under IL-10-neutralizing conditions. These findings provide direct support for targeting IL-10 as an approach to therapy in human VL.
Medical subject headings
- Interleukin-10
- Leishmania donovani
- Leishmaniasis, Visceral
- Spleen