A new FOXO pathway required for leukemogenesis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21884926.
- Also identified by DOI 10.1016/j.cell.2011.08.019.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In cancer, the FOXO family of transcription factors functions as tumor suppressors and is directly inactivated by oncogenic signaling through the PI3K/AKT pathway. Now, Skykes et al. (2011) identify a paradoxical requirement for FOXOs in the maintenance of leukemia-initiating cells.