When T cells run out of breath: the HIF-1α story.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 21884928.
- Also identified by DOI 10.1016/j.cell.2011.08.018.
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Abstract
In this issue, Dang et al. (2011) report a role for the hypoxia-induced transcription factor HIF-1α in regulating the differentiation of T cell subsets that impact both inflammation and its resolution. Their findings illustrate how metabolic signals can alter the balance between inflammation and tolerance and present a potential therapeutic opportunity for the treatment of diseases associated with chronic inflammation.