Breaking the cell cycle of HSCs by p57 and friends.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21885016.
- Also identified by DOI 10.1016/j.stem.2011.08.005.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The cell cycle regulators involved in maintaining the quiescence, and thereby the self-renewal capacity, of somatic stem cells have long been elusive. Two new Cell Stem Cell articles in this issue (Matsumoto et al., 2011; Zou et al., 2011) now show that the CDK inhibitor p57 is a crucial brake for cycling HSCs, and links self-renewal activity to cell cycle quiescence.
Medical subject headings
- Adult Stem Cells
- Cell Survival
- Cellular Senescence
- Cyclin D1
- Cyclin-Dependent Kinase Inhibitor p27
- Cyclin-Dependent Kinase Inhibitor p57
- HSC70 Heat-Shock Proteins
- Hematopoietic Stem Cells