Predicting the physiological role of circadian metabolic regulation in the green alga Chlamydomonas reinhardtii.
basic_science · Level V
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- Record sourced from PubMed, PMID 21887226.
- Also identified by DOI 10.1371/journal.pone.0023026 and PMC identifier PMC1065353.
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Abstract
Although the number of reconstructed metabolic networks is steadily growing, experimental data integration into these networks is still challenging. Based on elementary flux mode analysis, we combine sequence information with metabolic pathway analysis and include, as a novel aspect, circadian regulation. While minimizing the need of assumptions, we are able to predict changes in the metabolic state and can hypothesise on the physiological role of circadian control in nitrogen metabolism of the green alga Chlamydomonas reinhardtii.