Nanoparticles targeting the infarcted heart.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21899318.
- Also identified by DOI 10.1021/nl2025882 and PMC identifier 3192253.
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Abstract
We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in diameter were conjugated with a ligand specific to AT1. The nanoparticles were able to specifically target cardiac cells in vitro, and in the infarcted heart after intravenous injection in vivo. This system may be useful for delivering therapeutic agents specifically to the infarcted heart.
Medical subject headings
- Cardiovascular Agents
- Drug Delivery Systems
- Myocardial Infarction
- Nanoparticles