Serine metabolism: some tumors take the road less traveled.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21907134.
- Also identified by DOI 10.1016/j.cmet.2011.08.004 and PMC identifier 3172581.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Cancer cells display a reprogramming of metabolism that facilitates growth but addicts them to key enzyme activities. Two studies in Nature and Nature Genetics find that the gene encoding the serine biosynthetic enzyme phosphoglycerate dehydrogenase (PHGDH) is amplified in a subset of cancers and contributes to tumor cell growth.