Abolition by omeprazole of aspirin induced gastric mucosal injury in man.
rct · Level II
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- Record sourced from PubMed, PMID 2190865.
- Also identified by PMC identifier 1378564.
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Abstract
This study investigates whether aspirin injury to the human gastric mucosa can be prevented by profound acid suppression with omeprazole, in a randomised, double blind, crossover design according to latin square. It was concluded that profound acid suppression can prevent aspirin induced gastric mucosal injury in normal subjects. This approach may prevent the development of peptic ulcers and their complications in patients taking aspirin and other non-steroidal anti-inflammatory drugs.
Medical subject headings
- Aspirin
- Gastric Acid
- Gastrointestinal Hemorrhage
- Omeprazole